5 years ago
Researchers discover proton regulator of essential cancer microRNA
Zhang lab used nuclear magnetic resonance imagine to discover an RNA-centric mechanism for regulating the creation of a microRNA in response to environmental stimuli.
Tag: Faculty & Lab News
6 years ago
UNC SOM Annual Faculty Meeting: Share your feedback
Please take a moment to complete a brief survey and share your thoughts on the School of Medicine’s annual faculty meeting, held Oct. 14.
6 years ago
David Paul, PhD and Wolfgang Bergmeier, PhD publish latest research in Blood
Talin-1 is the principal platelet Rap1 effector of integrin activation PLATELETS AND THROMBOPOIESIS September 3, 2020 Recent Blood paper publication, collaborated with Mark Ginsberg, MD at UCSD to identify a unique mechanism regulating integrin-mediated platelet adhesion at sites of vascular injury
6 years ago
Tackling tough challenges
By fostering collaborative research teams, Carolina is accelerating new discoveries and solutions to emerging challenges. Read the UNC.edu feature on some of the work faculty, students, postdocs, and fellows are spearheading.
6 years ago
Wolfgang Bergmeier appointed to Haima Therapeutics Scientific Advisory Board
Haima Therapeutics, a pre-clinical biotechnology company focused on developing platelet-inspired therapies to mitigate bleeding dysfunctions, announced today the appointment of Wolfgang Bergmeier to its Scientific Advisory Board (SAB). Dr. Bergmeier is a world-renowned scientist and key opinion leader in platelet biology, hemostasis, and thrombosis. He is currently a Professor of Biochemistry and Biophysics at The …
6 years ago
Researchers Reveal Safeguarding of a Key DNA Sensor in the Innate Immune System
Led by Qi Zhang, PhD, and Robert McGinty, MD, PhD, UNC-Chapel Hill scientists used cryo-electron microscopy technology to produce the first-ever high-resolution structure of the protein cGAS bound to the DNA packaging unit inside human cell nuclei, revealing how cGAS responds to foreign or damaged DNA, but not the body’s healthy DNA.
6 years ago
Ramsden, Gupta awarded 5-year, $8.8 million grant to study an enzyme that has important implications for breast and ovarian cancer
The National Cancer Institute has awarded a team led by UNC Lineberger’s Dale Ramsden, PhD, professor in the UNC School of Medicine Department of Biochemistry and Biophysics, a five-year, $8.8 million program project grant to study an enzyme called DNA polymerase theta. This enzyme is part of an important pathway that repairs damage to genomes, with particular significance …
6 years ago
New faculty support website centralizes key resources
Developed to easily reach faculty, the site connects to key resources for well-being, racism and equity and teaching.
6 years ago
UNC-Chapel Hill ranked 30th in 2020 Academic Ranking of World Universities
Carolina also ranked in the top 20 for 11 academic subject areas according to the 2020 Academic Ranking of World Universities released by the Shanghai Ranking Consultancy on August 15.
6 years ago
Pengda Liu receives AIMS Award: Progress Toward a Targeted Oncology Treatment
After completing his PhD degree studying transcriptional kinases in yeast, Pengda Liu had one goal for his career: to make a difference for human health. Today, he is on the cusp of advancing a promising compound into the drug discovery and development pipeline. If successful, it would become the first targeted treatment for patients with …
6 years ago
Liu and Damania Labs identified new proteins controlling cGAS activation
Hyperactivation of innate immunity results in autoimmune diseases, while deficiency in innate immunity is prone to tumorigenesis. Thus, the activity of innate immune signaling is tightly controlled but the regulatory mechanisms have not been fully elucidated. Recently, the labs of Liu and Damania published a study in iScience revealing a role of the bacterial protein streptavidin in binding and facilitating cGAS activation.
6 years ago
Dowen lab untangles another part of the 3D genome
It is known that the three-dimensional organization of the genome within the nucleus is important for proper gene expression and ultimately development. The mechanisms behind this organization, however, are not yet fully understood. Recently, the lab of Jill Dowen, PhD, published a study in Epigenetics & Chromatin solving a piece of this complex puzzle.