December 15, 2020
COVID-19 is associated with derangements in biomarkers of coagulation and endothelial cell function and has been likened to abnormalities seen in sepsis. Emma Bouck and Alisa Wolberg, PhD collaborated with investigators at the University of Utah to show that both COVID-19 and sepsis are associated with activation of mechanisms that promote clot formation and clot …
December 15, 2020
Research in the Aleman Lab is centered on basic mechanisms regulating erythropoiesis in health and disease. Differentiation of hematopoietic stem cells down the erythroid track requires coordinated gene expression, including RNA regulation, and accumulation of iron for hemoglobin production. Our current work focuses on a family of bifunctional proteins (poly C binding proteins) which both regulate RNA processing and chaperone iron within cells. Using biochemical, cellular, and in vivo models we explore the cross talk between iron trafficking and RNA regulation mediated by poly C binding proteins and how these activities are modulated by disease.
December 14, 2020
The Bahnson Research Group studies Redox Biology in Cardiovascular Disease and the development of targeted nanocarriers to deliver therapeutics.
December 9, 2020
Congratulations to Silvio Antoniak, Phd with NCSU collaborator James C. Bonner! Grant application titled “Role of PAR-2 in nanoparticle modulation of allergic lung disease” The NC TraCS proposal investigates the contribution of lung macrophage PAR2 on allergic airway disease caused by multi-walled carbon nanotubes (MWCNTs). We propose that common allergens like house dust mite allergens …
December 2, 2020
R35 grant awarded to Nigel Mackman, PhD (PI) from NHLBI/NIH The award is a 7 year grant with $600,000/year directs costs and a total amount of $6.46million. The title is “Tissue factor-dependent coagulation in thrombosis and immune responses”. The proposal will study the mechanisms of thrombosis in cancer and viral infections, including influenza A infection …
November 5, 2020
Congratulations to Patrick Ellsworth, MD, awarded the ASH Research Restart Award. This award is for $50,000 for the twelve-month term beginning November 2020. One of the Society’s newest programs, the ASH Research Restart Award program is designed to reduce the impact that the global COVID-19 pandemic response has had on the progression of research and …
October 20, 2020
Talin-1 is the principal platelet Rap1 effector of integrin activation PLATELETS AND THROMBOPOIESIS| September 3, 2020 Recent Blood paper publication, collaborated with Mark Ginsberg, MD at UCSD to identify a unique mechanism regulating integrin-mediated platelet adhesion at sites of vascular injury: Wofgang Bergmeier, PhD and David Paul, PhD are co-authors on this study, showing that …
October 19, 2020
The National Institutes of Health hereby awards this grant ~ Congratulations to Dr. Wolfgang Bergmeier, he is part of this PPG which is spearheaded by investigators at the University of California at San Diego and the La Jolla Institute for Immunology. Project Period: 08/05/2020 – 07/31/2025 Project Title: Cellular Mechanisms of Inflammation, Hemostasis, and Thrombosis …
September 27, 2020
The Oncologist “D-dimer enhances risk targeted thromboprophylaxis in ambulatory cancer patients” Background: Thromboprophylaxis for ambulatory cancer patients is effective, although uncertainties remain on who should be targeted. using D-dimer values from individuals enrolled to the AVERT trial, we sought to identify and validate a more efficient VTE risk threshold for thromboprophylaxis. Read Publication here
September 16, 2020
Congratulations to Nigel Mackman on receiving the ATVB Highly Cited Award! As a member of the Editorial Board who publish their high level science in ATVB, we will be recognizing the publication by Editorial Board members that were the most highly cited in the determination of the 2019 impact factor. Manuscript: Tissue Factor: An Essential …
September 2, 2020
What is myocarditis? How is it linked to COVID-19? And why is it a concern for athletes? Dr. Silvio Antoniak explains- One of the more concerning side effects of COVID-19 infection is myocarditis — a once rare condition of inflammation of the heart, leading to scar tissue build-up and a weakening of the heart. A …
September 2, 2020
Congratulations to Jean Marie Mwiza, a graduate research assistant in the Bergmeier and Wolberg Labs, for recently receiving an F31 research fellowship award from NIH’s NHLBI. Jean Marie’s fellowship provides ongoing stipend support, beginning January, 2021, for his project, titled “Determining the Platelet Signaling Pathway(s) Critical in Venous Thrombosis Pathogenesis”.