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NC TraCS awarded funding for a $5K-50K grant application submitted by Rebecca Traub, MD, and Xiaoyan Li, MD,  PhD, titled, “Predictive modeling of disease-modifying immunophenotypes in ALS patients.” Traub is an associate professor in the Neuromuscular Division and Li is a former UNC Neurology resident who is now an assistant professor at Duke.

Traub and Li propose to adopt mass cytometry and in situ imaging mass cytometry to derive single-cell immunomics data from sporatic amyotrophic lateral sclerosis (sALS) patients and controls. Their hypothesis is that immune disparities between sALS patients contribute to varied clinical presentation and outcome. They aim to carry out analyses of immunophenotyping data of sALS cases and controls to identify disease-associated profiles/populations.

The North Carolina Translational and Clinical Sciences Institute (NC TraCS) provides a variety of pilot funding opportunities to facilitate the transfer of research findings to clinical practice in order to improve the health of the people of North Carolina. The grant program is designed to encourage and facilitate novel clinical and translational research in its many forms. Cross-disciplinary basic science research addressing the development of therapies, diagnostics or devices applicable to human disease, clinical research/trials, epidemiological studies, and/or community-based research are considered eligible for these awards.

The TraCS $5K-50K grant awards one-year grants of up to $25,000 which must be matched for total awards of up to $50,000.