Dr. Saskia Neher Associate Professor of Biochemistry and Biophysics received an R01 for her project “Lipoprotein Lipase Through the Secretory System” from the National Heart, Lung, And Blood Institute of the National Institutes of Health (NHLBI) for $1,527,456 for the period of 12/21/2022 through 11/30/2026.
PI: Dr. Saskia Neher
Project Title: “Lipoprotein Lipase Through the Secretory System”
Sponsor: National Heart, Lung, And Blood Institute of the National Institutes of Health (NHLBI)
Award Amount: $1,527,456
Grant Award type: R01
Project Dates: 12/21/2022 – 11/30/2026
The Research Project Grant (R01) is the original and historically oldest grant mechanism used by NIH. The R01 provides support for health-related research and development based on the mission of the NIH.
The Neher lab primarily studies proteins involved in lipid metabolism. They use structural biology, biochemistry, and microscopy to answer questions about enzyme function, inhibition, and trafficking. This new award focuses on lipoprotein lipase, the main enzyme responsible for hydrolyzing triglycerides from circulating lipoproteins. It will allow the lab to better understand how lipoprotein lipase moves from cells into the blood in response to insulin signaling.