Large Aggregates of ALS-causing Protein Might Actually Help Brain Cells

Nikolay Dokholyan, PhD

UNC School of Medicine scientists led by Nikolay Dokholyan, Michael Hooker Distinguished Professor of Biochemistry and Biophysics, add to evidence that small aggregates of SOD1 protein are the brain-cell killing culprits in ALS, but the formation of larger, more visible, and fibril-like aggregates of the same protein may protect brain cells.

Brian Strahl Awarded NIGMS Outstanding Investigator Grant

Brian Strahl, PhD, receives R35 MIRA award

Congratulations to Brian Strahl, Professor & Vice-Chair of the Department of Biochemistry & Biophysics, for being selected to receive an R35 Maximizing Investigators’ Research Award (MIRA) from the National Institutes of Health.

Alumni Seth Zimmerman Awarded 2017 JCS Prize

photo of Seth Zimmerman alumni Kuhlman lab

The winner of the 2017 Journal of Cell Science (JCS) Pr … Continued

Prognostic tool could identify high-risk breast cancer patients

Xian Chen, PhD

In the journal Cell Chemical Biology, researchers led by Biochemistry and Biophysics Associate Professor and Faculty Director, Quantitative Proteomics Center for Disease Marker Discovery, Xian Chen, PhD, report on potential prognostic tool that could be used to identify high-risk patients within particular subtypes of breast cancer.

Researchers define structure, function of enzyme key to blood cancers

Greg Wang PhD

In the journal Nature, Greg Wang, PhD, assistant professor of Biochemistry and Biophysics and Cell biology Program, and colleagues reported findings about the structure and function of the DNMT3A enzyme complex, which helps control gene expression.

Gene therapy researchers find viral barcode to cross the blood-brain barrier

Aravind Asokan, PhD

Congratulations to Aravind Asokan PhD, Assistant Professor of Genetics with a Joint Appointment in Biochemistry and Biophysics and Lineberger Comprehensive Cancer Center member who led UNC scientists to reveal how certain gene-carrying AAV vectors can penetrate the brain more efficiently to treat brain and spinal cord conditions, while reducing liver payload.

Strahl named Smithies Investigator

Jen Jen Yeh, MD, and Brian Strahl, PhD

Congratulations Brian Strahl, PhD, professor and vice chair of the department of biochemistry and biophysics, and Jen Jen Yeh, MD, professor and vice chair of research for the department of surgery, who were selected by the UNC School of Medicine for the annual award in honor of Oliver Smithies, UNC’s first Nobel Prize winner.

2017 Staff Excellent Award winners John Hutton and Tina Leisner PhD

photo of John Hutton and Tina Leisner PhD

UNC Chapel Hill department of Biochemistry and Biophysi … Continued