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Greg Wang PhD

2 years ago

Scientists uncover a new approach for treating aggressive cancer (Greg Wang lab)

Researchers at UNC-CH Biochemistry and Biophysics and Lineberger have uncovered a new role of a chromatin-modulatory enzyme, termed EZH2, during cancer development. They then developed a new therapeutic approach with a potent small-molecule inhibitor of this enzyme. Published online "EZH2 noncanonically binds cMyc and p300 through a cryptic transactivation domain to mediate gene activation and promote oncogenesis" in Nature Cell Biology on February 24, 2022.

Jared Peck Dr. Jonathan Fay and Dr. Joshua Strauss

2 years ago

UNC’s Cryo-EM Core facility develops new methodology for high-speed and high-resolution cryogenic electron microscopy technology

Our researchers optimized the function of a microscope for cryogenic electron microscopy (CryoEM) to maximize the throughput and performance of the microscope housed in the UNC-Chapel Hill Cryo-EM Core Facility. This method development is demonstrated successful for structural studies of GPCRs, a large group of signaling proteins that includes many therapeutic targets with unknown structures.