Research in the Strahl lab helps to piece together how the 'histone code' contributes to chromatin regulation. Image credit: Scott Rothbart, PhD.

New research from the lab of Dr. Brian Strahl, associate professor of Biochemistry and Biophysics, has shown how a protein called UHRF1 “reads” the histone code in a specific way to perform an important cellular function.

Congratulations to Dr. Henrik Dohlman who will become an Associate Editor of Journal of Biological Chemistry, a peer-reviewed journal, effective July 2013 for a five-year term.

At top is a structural model of uniRapR domain which binds small molecule rapamycin. The bottom left depicts inactive state of the protein of interest modified with uniRapR domain. Binding of rapamycin and uniRapR reactivates the protein (bottom right).

In the first application of this approach, the UNC researchers showed how a protein called Src kinase influences the way cells extend and move, a previously unknown role that is consistent with the protein’s ties to tumor progression and metastasis.

Congratulations to Biochemistry and Biophysics faculty Brian Kuhlman who was promoted from associate professor to full professor effective March 1, 2013.

Three scientists at the UNC-CH (Marcey Waters, Brian Strahl, Xian Chen) have received a $1 million grant from the W.M. Keck Foundation’s Medical Research Program to study a widespread but largely unexplored phenomenon that may be implicated in many diseases, including cancer.

Congratulations to Dr. Qi Zhang, Assistant Professor of Biochemistry and Biophysics, who has received the 2013 Basil O’Connor Starter Scholar Research Award from the March of Dimes Foundation.

The protein Ras plays an important role in cellular growth control. Researchers have focused on the protein because mutations in its gene are found in more than 30 percent of all cancers, making it the most prevalent human oncogene.

PCLS utilizing a group of amino acids to engage with a chemical marker that signals gene activation

Research from the Wang and Strahl labs has shed new light on how epigenetic signals may function together to determine the ultimate fate of a stem cell.

Congratulations to Dr. Charles Carter, Jr., Professor of Biochemistry & Biophysics, who was elected as a 2012 AAAS fellow.

Congratulations to Nikolay Dokholyan, Professor of Biochemistry and Biophysics, for his election as a 2012 APS Fellow.

Scott Rothbart, PhD (left) and Brian Strahl, PhD (right)

Sept. 30, 2012 - New research from the Strahl lab has established the first link between the two most fundamental epigenetic tags -- histone modification and DNA methylation -- in humans.

Protein S unplugged–a new wrinkle on the old theme (ATVB; Oct 2012, pg 2387-2393)

A schematic from Dr. Majumder's paper "Inhibition of Intrinsic Xase by Protein S - A Novel, Regulatory role of Protein S Independent of Activated Protein C" in the October 2012 issue of Arteriosclerosis, Thrombosis, and Vascular Biology has been chosen as the cover image.

Tag: Faculty & Lab News

Researchers in the Strahl lab identify another piece of the “histone code” puzzle

Dohlman selected as JBC associate editor

UNC researchers engineer ‘protein switch’ to dissect role of cancer’s key players

Kuhlman Promoted to Full Professor

UNC scientists awarded $1 million to develop new tools to study the protein methylome

Zhang awarded March of Dimes Starter Scholar award

New mechanism for cancer progression discovered by UNC and Harvard researchers

Wang discovers information from outside the genome influences stem cell differentiation, cancer development

Charles Carter elected as 2012 AAAS Fellow

Nikolay Dokholyan elected as a 2012 American Physical Society Fellow

Scientists in the Strahl lab find missing link between players in the epigenetic code

Rinku Majumder has the cover article in the October 2012 issue of ATVB