Department of Genetics faculty, postdocs, students and collaborators published 40 papers during September 28th – October 31st 2025.
Polygenic risk score for type 2 diabetes shows context-dependent effects across populations.
Guo B, Cai Y, Kim D, Smit RAJ, Wang Z, Iyer KR, Hilliard AT, Haessler J, Tao R, Broadaway KA, Wang Y, Pozdeyev N, Stæger FF, Yang C, Vanderwerff B, Patki AD, Stalbow L, Lin M, Rafaels N, Shortt J, Wiley L, Stanislawski M, Pattee J, Davis L, Straub PS, Shuey MM, Cox NJ, Lee NR, Jørgensen ME, Bjerregaard P, Larsen C, Hansen T, Moltke I, Meigs JB, Stram DO, Yin X, Zhou X, Chang KM, Clarke SL, Guarischi-Sousa R, Lankester J, Tsao PS, Buyske S, Graff M, Raffield LM, Sun Q, Wilkens LR, Carlson CS, Easton CB, Liu S, Manson JE, Marchand LL, Haiman CA, Mohlke KL, Gordon-Larsen P, Albrechtsen A, Boehnke M, Rich SS, Manichaikul A, Rotter JI, Yousri NA, Irvin RM; biobank at the Colorado Center for Personalized Medicine (CCPM); VA Million Veteran Program (MVP); Gignoux C, North KE, Loos RJF, Assimes TL, Peters U, Kooperberg C, Raghavan S, Highland HM, Darst BF.
Nat Commun. 2025 Oct 1;16(1):8632. doi: 10.1038/s41467-025-63546-4.
PMID: 41034193 Free PMC article.
Culviner PH, Frey AM, Liu Q, Ha DTM, Thai PVK, Thu DDA, Quang NL, Calderon R, Lecca L, Caws M, Dunstan SJ, Murray MB, Thuong NTT, Fortune SM.
Cell. 2025 Sep 30:S0092-8674(25)01036-0. doi: 10.1016/j.cell.2025.09.005. Online ahead of print.
PMID: 41033311
Singh NP, Wu EY, Fan J, Love MI, Patro R.
Genome Res. 2025 Oct 1;35(10):2326-2338. doi: 10.1101/gr.279981.124.
PMID: 40841168 Free PMC article.
Mathai DS, Robinson JO, Wagner K, Neitzke-Spruill L, Berrones D, Anderberg JL, Frederick RM, Cruz VZ, Muñoz JS; Latin American Trans-Ancestry INitiative for OCD genomics; Brazilian Obsessive-Compulsive Spectrum Disorder Working Group; Rodriguez CI, Averill LA, Crowley JJ, Storch EA, McGuire AL.
Braz J Psychiatry. 2025 Sep 29. doi: 10.47626/1516-4446-2025-4316. Online ahead of print.
PMID: 41024388
Lu KY, Yang X, Eldridge MJG, Sun R, Giorgio RT, Morris BI, Wagner NJ, Hardy B, Axtman M, Rowe SE, Wang X, Fowler VG Jr, Liu Q, Helaine S, Pearce KH, Conlon BP.
Nat Microbiol. 2025 Oct 10. doi: 10.1038/s41564-025-02124-2. Online ahead of print.
PMID: 41073665
Cruz DE, Deng S, Tahir UA, Chen ZZ, Benson MD, Tuftin B, Chen J, Farrell L, Shen D, Meyer M, Lange E, Gao Y, Hall ME, Tracy RP, Rich SS, Taylor K, Manichaikul A, Rotter JI, Sofer T, Wilson JG, Gerszten RE, Raffield LM; National Heart, Lung, and Blood Institute TOPMed (Trans-Omics for Precision Medicine) Consortium.
HGG Adv. 2025 Oct 8:100529. doi: 10.1016/j.xhgg.2025.100529. Online ahead of print.
PMID: 41069105
High-throughput cytological profiling uncovers genotype-phenotype associations in Mycobacterium tuberculosis clinical isolates.
Liu Q, Liu YJ, Liu R, Culviner PH, Wang X, Wolf ID, Chen K, Chen Y, Xiao Y, Zhang G, Sun R, Wakabayashi S, Howard NC, Gan M, Rubin EJ, Fortune SM, Zhu J.
mSystems. 2025 Oct 9:e0097225. doi: 10.1128/msystems.00972-25. Online ahead of print.
PMID: 41065399
Kim D, Highland HM, Smit RAJ, Hysong MR, Buchanan VL, Young KL, Zhao C, Spracklen CN, Kilpeläinen TO, Guo B, Darst BF, Cai Y, Wang Z, Lundin J, Berndt SI, Manson JE, Marouli E, Lange L, Lange E, Fornage M, Gignoux CR, Haiman CA, Rich SS, Buyske S, Loos RJF, Kooperberg C, Peters U, Avery CL, Gordon-Larsen P, Graff M, Raffield LM, North KE.
Genome Med. 2025 Oct 6;17(1):113. doi: 10.1186/s13073-025-01522-9.
PMID: 41053791 Free PMC article.
Vasilevsky NA, Toro S, Matentzoglu N, Flack JE, Mullen KR, Hegde H, Gehrke S, Whetzel PL, Shwetar Y, Harris NL, Ngu MS, Alyea GL, Kane MS, Roncaglia P, Sid E, Thaxton CL, Wood V, Abraham RS, Achatz MI, Ajuyah P, Amberger JS, Babb L, Baker J, Balhoff JP, Berg JS, Bhalla A, Bofill-De Ros X, Braun IR, Broeren EC, Byer BK, Byrne AB, Callahan TJ, Carmody LC, Chan LE, Clause AR, Cohen JS, DeLuca M, Deuitch NT, Flowers M, Fraser J, Fujiwara T, Gitau V, Goldstein JL, Gration D, Groza T, Gyori BM, Hankey W, Hilton JA, Himmelstein DS, Hong SS, Hoyt CT, Huether R, Hurwitz E, Jacobsen JOB, Kikuchi A, Köhler S, Korn DR, Lagorce D, Laraway BJ, Li JY, Malheiro AJ, McLaughlin J, Meldal BHM, Mohan S, Moxon SAT, Munoz-Torres MC, Nelson TH, Nicholas FW, Ochoa D, Olson D, Oprea TI, Oskotsky TT, Osumi-Sutherland D, Paris K, Parkinson HE, Pendlington ZM, Peng XP, Pizzino A, Plon SE, Powell BC, Ratliff JC, Rehm HL, Remennik L, Riggs ER, Roberts S, Robinson PN, Ross JE, Schaper K, Schilder BM, Schmidt JL, Sharp EW, Similuk MN, Smedley D, Sneddon TP, Sparks R, Stefancsik R, Stupp GS, Sundar S, Takatsuki T, Tammen I, Tshering KC, Unni DR, Valasek E, Vanderver A, Wagner AH, Webb RF, Welter D, Yaya-Stupp D, Zankl A, Zhang XA, McMurry JA, Chute CG, Hamosh A, Mungall CJ, Haendel MA.
Genetics. 2025 Oct 6:iyaf215. doi: 10.1093/genetics/iyaf215. Online ahead of print.
PMID: 41052288
Josiassen RC, Xavier RM, Dietterich TE, Harner MK, Filmyer DM, Houpt C, Lichtenstein ML, Farrell M, Shaughnessy RA, Lazaro-Munoz G, Berg JS, Sullivan PF.
Schizophr Bull Open. 2025 Sep 4;6(1):sgaf019. doi: 10.1093/schizbullopen/sgaf019. eCollection 2025 Jan.
PMID: 41050266 Free PMC article.
Lim MY, Lee K, Johnsen JM, Key NS.
Haemophilia. 2025 Oct 10. doi: 10.1111/hae.70143. Online ahead of print.
PMID: 41071185
Zhao Y, Lockhart S, Liu J, Li X, Cortes A, Hua X, Gardner EJ, Kentistou KA, Cañadas-Garre M, Fabian L, Ho K, Timpson N, Lo Y, Davitte J, Savage DB, Buser-Doepner C, Ong KK, Zhang H, Scott R, O’Rahilly S, Perry JRB.
Nat Genet. 2025 Oct;57(10):2436-2444. doi: 10.1038/s41588-025-02364-2. Epub 2025 Oct 10.
PMID: 41073786
Nigam A, Mederos MA, Aksoy YA, Alzumaili B, Bani MA, Fuchs T, Al Ghuzlan A, Gill AJ, Glover AR, Papachristos A, Repaci A, De Leo A, Tallini G, Ahmadi S, Clausen B, Najdawi F, Barletta J, Shaha AR, Spanheimer P, Tuttle RM, Wong RJ, Xu B, Ghossein RA, Ganly I, Untch BR.
Surgery. 2025 Oct 9:109764. doi: 10.1016/j.surg.2025.109764. Online ahead of print.
PMID: 41073156
Masson HO, Di Giusto P, Kuo CC, Malm M, Lundqvist M, Sievertsson Å, Berling A, Tegel H, Hober S, Uhlen M, Grassi L, Robasky K, Hsieh CL, Hatton D, Rockberg J, Lewis NE.
Proc Natl Acad Sci U S A. 2025 Oct 14;122(41):e2506036122. doi: 10.1073/pnas.2506036122. Epub 2025 Oct 7.
PMID: 41055974
Weinstock JS, Chaudhry SA, Ioannou M, Viskadourou M, Reventun P, Jakubek YA, Liggett LA, Laurie C, Broome JG, Khan A, Taylor KD, Guo X, Peyser PA, Boerwinkle E, Chami N, Kenny EE, Loos RJ, Psaty BM, Tracy RP, Brody JA, Yun JH, Cho MH, Vasan RS, Kardia SL, Smith JA, Raffield LM, Bidulescu A, O’Brien EC, de Andrade M, Rotter JI, Rich SS, Tracy RP, Chen YI, Gu CC, Hsiung CA, Kooperberg C, Haring B, Nassir R, Mathias R, Reiner A, Sankaran VG, Lowenstein CJ, Blackwell TW, Abecasis GR, Smith AV, Kang HM, Natarajan P, Jaiswal S, Bick A, Post WS, Scheet P, Auer P, Karantanos T, Battle A, Arvanitis M.
Nat Commun. 2025 Oct 16;16(1):9194. doi: 10.1038/s41467-025-64236-x.
PMID: 41102182 Free PMC article.
Walker AE, Gao X, Wang Q, De la Cruz G, Li D, Perou CM, Saltz J, Marron JS, Hoadley KA, Troester MA.
PLoS Med. 2025 Oct 15;22(10):e1004647. doi: 10.1371/journal.pmed.1004647. Online ahead of print.
PMID: 41091832
N-Alkyl Sulfamates as a New Class of nsP2 Cysteine Protease Inhibitors with Broad-Spectrum Antialphaviral Activity.
Ghoshal A, Sears JD, Hossain MA, Tse EG, Howell S, Burdick JE, Morales NL, Martinez SA, Law I, Streblow ZJ, Streblow DN, Couñago RM, Moorman NJ, Heise MT, Willson TM.
J Med Chem. 2025 Oct 15. doi: 10.1021/acs.jmedchem.5c01802. Online ahead of print.
PMID: 41090377
Höffler KD, Katrinli S, Halvorsen MW, Stavrum AK, O’Connell KS, Shadrin A, Djurovic S, Andreassen OA, Crowley JJ, Haavik J, Hagen K, Kvale G, Ressler K, Hansen B, Soares JC, Fries GR, Smith AK, Le Hellard S.
Epigenetics Chromatin. 2025 Oct 14;18(1):69. doi: 10.1186/s13072-025-00627-0.
PMID: 41088295 Free PMC article.
Hamad SH, Joshi H, Hess T, Jefferys SR, Saleh Z, Bendjilali N, Sellers RS, Zhu G, Shrank T, Moore RT, Corcoran D, Simon JM, Spitz FR, Shersher D, Major MB, Weissman BE.
Cancer Gene Ther. 2025 Oct 11. doi: 10.1038/s41417-025-00966-w. Online ahead of print.
PMID: 41076449
Little TS, Wang Y, Chaudhari AP, Budayr OM, Tetterton-Kellner JG, Bastian A, Brown AD, Jasiewicz NE, McCue A, Earp HS, Miller BC, Nguyen J.
J Control Release. 2025 Oct 15:114340. doi: 10.1016/j.jconrel.2025.114340. Online ahead of print.
PMID: 41106435
Jalazo ER, Weisenfeld LA, Ligezka A, Perfetti R, Muenzer J.
JIMD Rep. 2025 Oct 12;66(6):e70043. doi: 10.1002/jmd2.70043. eCollection 2025 Nov.
PMID: 41089670 Free PMC article.
McCaw ZR, Gao J, Dey R, Tucker S, Zhang Y; insitro Research Team; Gronsbell J, Li X, Fox E, O’Dushlaine C, Soare TW.
Am J Hum Genet. 2025 Oct 13:S0002-9297(25)00368-4. doi: 10.1016/j.ajhg.2025.09.012. Online ahead of print.
PMID: 41086816
Burton BK, Fertek D, Chin PS, Ho C, Giugliani R, van den Hout JMP, Magner M, Ezgü F, AlSayed M, Muenzer J, Okuyama T, Jones SA.
Mol Genet Metab. 2025 Sep 29;146(3):109248. doi: 10.1016/j.ymgme.2025.109248. Online ahead of print.
PMID: 41075684
Wang M, Zheng Y, Lai M, Saake E, Liu X, Guo X, Taylor KD, Huan T, Joehanes R, Nannini DR, Zhang K, Lake NJ, Castellani CA, Rich SS, Rotter JI, Liu Y, Raffield LM, Carson AP, Fornage M, Ma J, Arking DE, Hou L, Levy D, Liu C.
Aging Cell. 2025 Oct 24:e70279. doi: 10.1111/acel.70279. Online ahead of print.
PMID: 41132105
Association between neutrophil to lymphocyte ratio and Alzheimer’s disease in large biobank cohorts.
Drzymalla E, Avery C, Palta P, Reiner AP, Sun Q, Raffield LM.
J Alzheimers Dis. 2025 Oct 23:13872877251386813. doi: 10.1177/13872877251386813. Online ahead of print.
PMID: 41129721
Bei C, Wang X, Gan M, Takiff HE, Rubin EJ, Zhu J, Gao Q, Liu Q.
Brief Bioinform. 2025 Aug 31;26(5):bbaf557. doi: 10.1093/bib/bbaf557.
PMID: 41115211 Free PMC article.
Fortuno C, Frone MN, Mester J, de la Hoya M, Mai PL, Pesaran T, Achatz MI, Bassett R, Bustamante C, Crowley S, de Andrade KC, Evans DG, Feng B, Fuqua L, Harrell MI, Hatton JN, Huether R, Kesserwan C, Lee K, MacFarland SP, Maciaszek JL, Maxwell K, McGoldrick K, Murphy M, Nehoray B, Penkert J, Pinto EM, Plon SE, Schwartz-Levine A, Thompson AS, Wang W, Zambetti GP, Zelley K, James PA, Savage SA, Kratz CP, Spurdle AB.
Genome Med. 2025 Oct 22;17(1):128. doi: 10.1186/s13073-025-01536-3.
PMID: 41126324 Free PMC article. Review.
Wen H, Carpenter S, McGinnis K, Nelson A, Smith K, Hong T.
Gigascience. 2025 Oct 24:giaf136. doi: 10.1093/gigascience/giaf136. Online ahead of print.
PMID: 41134033
Shukla K, Wang Y, Spanheimer PM, Brunk E.
Clin Transl Sci. 2025 Oct;18(10):e70350. doi: 10.1111/cts.70350.
PMID: 41127930 Free PMC article.
Andermann TM, Zeng K, Guirales-Medrano S, Groth A, Ramachandran BC, Sun S, Sorgen AA, Hill L, Bush AT, Liu H, Jones C, Roach J, Conlon BP, Rao G, Chao NJ, Fodor AA, Sung AD.
OBM Transplant. 2025;9(3):10.21926/obm.transplant.2503255. doi: 10.21926/obm.transplant.2503255. Epub 2025 Aug 25.
PMID: 41114048 Free PMC article.
Shefchek K, Ziniel SI, McMurry JA, Brownstein CA, Brownstein JS, Riggs ER, Might M, Smedley D, Clugston A, Beggs AH, Paterson H, Robinson PN, Vasilevsky NA, Holm IA, Haendel MA.
EBioMedicine. 2025 Oct 30;121:105965. doi: 10.1016/j.ebiom.2025.105965. Online ahead of print.
PMID: 41172739
Alves T, Swanson KV, Girnary MS, Freire M, Moss K, Divaris K, Beck J, Santos PCP, Brickey WJ, Wrobel JA, Min HY, Syed M, Morelli T, Seaman WT, Preisser JS, Hu D, Preisser H, Makhanova N, Susin C, Vias NP, Styner M, Zhang S, Pirih FQ, Chang J, Gill HS, Lietzan AD, Webster-Cyriaque J, Ting JPY, Marchesan JT.
Proc Natl Acad Sci U S A. 2025 Nov 4;122(44):e2507092122. doi: 10.1073/pnas.2507092122. Epub 2025 Oct 27.
PMID: 41144672
Schoenrock SA, Gaines CH, Kumar P, Khan S, Farrington J, Ferris MT, de Villena FP, Valdar W, Bubier JA, Tarantino LM.
Psychopharmacology (Berl). 2025 Oct 27. doi: 10.1007/s00213-025-06901-z. Online ahead of print.
PMID: 41143948
Bauer AE, Jaholkowski P, Lu Y, Guintivano J, Hannigan LJ, Corfield EC, Tesli M, Andreassen OA, Li Y, Reichborn-Kjennerud T, Sullivan PF, Meltzer-Brody S, Havdahl A, Ask H.
EClinicalMedicine. 2025 Oct 9;89:103540. doi: 10.1016/j.eclinm.2025.103540. eCollection 2025 Nov.
PMID: 41140460 Free PMC article.
Varvoglis DN, Landrum KR, Comer LH, O’Daniel JM, Agala CB, Lee LM, Guillem JG.
Curr Oncol. 2025 Sep 30;32(10):549. doi: 10.3390/curroncol32100549.
PMID: 41149469 Free PMC article.
O’Daniel JM, Kobelka C, Foss K, Foreman AKM, Milko LV.
NEJM Evid. 2025 Nov;4(11):EVIDra2400455. doi: 10.1056/EVIDra2400455. Epub 2025 Oct 28.
PMID: 41147825 Review.
Huffman JE, Gaziano L, Al Sayed ZR, Judy RL, Raffield LM, Biddinger KJ, Charest B, Chopra A, Gagnon D, Guo X, Koledova V, Levin MG, Min YI, Pirruccello JP, Reza N, Ruan R, Verma SS, Venkatesh BA, Verma A, Yao J, Carr JJ, Casas JP, Cho K, Lima JAC, Post WS, Rader DJ, Ritchie MD, Shah A, Taylor KD, Terry JG, Rich SS, O’Donnell CJ, Phillips LS, Lunetta KL, Rotter JI, Wilson PWF, Gaziano JM, Damrauer SM; VA Million Veteran Program; Sun YV, Ellinor PT, Joseph J, Aragam KG.
Nat Genet. 2025 Oct 31. doi: 10.1038/s41588-025-02372-2. Online ahead of print.
PMID: 41174181
Gessner KH, Deal AM, Feinberg A, Myers S, Poulos K, Heiling H, Wobker S, Akella P, Bjurlin MA, Commander C, Milowsky MI, Nielsen ME, Raynor M, Smith AB, Wallen E, Johnson DC, Kim WY, Tan HJ.
J Urol. 2025 Oct 28:101097JU0000000000004832. doi: 10.1097/JU.0000000000004832. Online ahead of print.
PMID: 41151063
Sultana H, Kunar R, Matera AG.
Biochem Soc Trans. 2025 Oct 29;53(5):1387-1399. doi: 10.1042/BST20253036.
PMID: 41151055 Review.
Cox CE, Schumacher J, Lillie M, Carino J, Agrawal Y, Selfridge JM, Gallagher KK, Ollila DW, Casey DL, Greenberg CC, Spanheimer PM.
Ann Surg Oncol. 2025 Oct 27. doi: 10.1245/s10434-025-18631-9. Online ahead of print.
PMID: 41145934