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Dr. Brian Strahl 2024

5 months ago

UNC Scientists Uncover Hidden Role of Tumor Suppressor Gene in Protecting the Genome

In a surprising twist, UNC scientists discovered that SETD2, a tumor suppressor, also preserves nuclear structure during cell division—a hidden role that may explain its tumor-suppressive effects in cancer. UNC biochemists Brian Strahl, PhD, and Abid Khan, PhD, discovered that the enzyme also plays a crucial structural role in preserving the shape and integrity of the nucleus – part of the cell that stores DNA.