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Introduction

The COVID-19 pandemic has had an unprecedented impact on the well-being of the citizens of the United States, with millions of US citizens diagnosed with COVID-19 and deaths from COVID-19 continuing to snowball. The pandemic has also had the predicted major effects on the economy, with millions of people unemployed due to pandemic-related shutdown measures. Marsico Lung Institute researchers have been engaged in work to understand the virus, SARS-CoV-2, that leads to COVID-19 disease and to seek potential treatments. As Dean Wesley Burks, MD, said, referring to the School of Medicine’s COVID-19 research, “We are proud to play a central role in this work, and I truly believe we will have a positive impact on the course of this pandemic. We are not here by accident.”

Human bronchial epithelial cells at 96 hours after SARS-CoV-2 infection. Left image: Infected ciliated cells with strand of mucus (yellow) attached to cilia tips (blue). Right image: Higher power magnification image showing the structure and density of SARS-CoV-2 virions (red) produced by human airway epithelia. Camille Ehre, SARS-CoV-2 Infection of Airway Cells, N Engl J Med, 2020;383:969.

COVID-19-Related Publications by MLI Researchers

  1. Murr A, Lenze NR, Brown WC, Gelpi MW, Ebert CS Jr, Senior BA, Thorp BD, Zanation AM, Kimple AJ. Quantification of Aerosol Particle Concentrations During Endoscopic Sinonasal Surgery in the Operating Room. Am J Rhinol Allergy. 2021 Jul;35(4):426-431. doi: 10.1177/1945892420962335. PMID: 33012174.
  2. Clapp PW, Ruzycki CA, Samet JM, Zeman KL, Berntsen J, Sickbert-Bennett E, Weber DJ, Finlay WH, Martin AR, Bennett WD, Wilson KH; Centers for Disease Control and Prevention (CDC) Prevention Epicenters Program. A Simple HEPA Filtering Facepiece. Am J Infect Control. 2021 May 7:S0196-6553(21)00297-2. doi: 10.1016/j.ajic.2021.04.085. Epub ahead of print. PMID: 33971283.
  3. Huang N, Pérez P, Kato T, Mikami Y, Okuda K, Gilmore RC, Conde CD, Gasmi B, Stein S, Beach M, Pelayo E, Maldonado JO, Lafont BA, Jang SI, Nasir N, Padilla RJ, Murrah VA, Maile R, Lovell W, Wallet SM, Bowman NM, Meinig SL, Wolfgang MC, Choudhury SN, Novotny M, Aevermann BD, Scheuermann RH, Cannon G, Anderson CW, Lee RE, Marchesan JT, Bush M, Freire M, Kimple AJ, Herr DL, Rabin J, Grazioli A, Das S, French BN, Pranzatelli T, Chiorini JA, Kleiner DE, Pittaluga S, Hewitt SM, Burbelo PD, Chertow D; NIH COVID-19 Autopsy Consortium; HCA Oral and Craniofacial Biological Network, Frank K, Lee J, Boucher RC, Teichmann SA, Warner BM, Byrd KM. SARS-CoV-2 infection of the oral cavity and saliva. Nat Med. 2021 May;27(5):892-903. doi: 10.1038/s41591-021-01296-8. PMID: 33767405. PMCID: PMC8240394.
  4. Murr AT, Lenze NR, Gelpi MW, Brown WC, Ebert CS Jr, Senior BA, Thorp BD, Kimple AJ, Zanation AM. Quantification of Aerosol Concentrations During Endonasal Instrumentation in the Clinic Setting. Laryngoscope. 2021 May;131(5):E1415-E1421. doi: 10.1002/lary.29122. PMID: 33017067; PMCID: PMC7675733.
  5. Sickbert-Bennett EE, Samet JM, Prince SE, Chen H, Zeman KL, Tong H, Bennett WD. Fitted Filtration Efficiency of Double Masking During the COVID-19 Pandemic. JAMA Intern Med. 2021 Apr 16:e212033. doi: 10.1001/jamainternmed.2021.2033. Epub ahead of print. PMID: 33861307; PMCID: PMC8052601.
  6. Clapp PW, Sickbert-Bennett EE, Samet JM, Berntsen J, Zeman KL, Anderson DJ, Weber DJ, Bennett WD; US Centers for Disease Control and Prevention Epicenters Program. Evaluation of Cloth Masks and Modified Procedure Masks as Personal Protective Equipment for the Public During the COVID-19 Pandemic. JAMA Intern Med. 2021 Apr 1;181(4):463-469. doi: 10.1001/jamainternmed.2020.8168. Erratum in: JAMA Intern Med. 2021 Apr 1;181(4):570. PMID: 33300948; PMCID: PMC7729588.
  7. Wahl A, Gralinski LE, Johnson CE, Yao W, Kovarova M, Dinnon KH 3rd, Liu H, Madden VJ, Krzystek HM, De C, White KK, Gully K, Schäfer A, Zaman T, Leist SR, Grant PO, Bluemling GR, Kolykhalov AA, Natchus MG, Askin FB, Painter G, Browne EP, Jones CD, Pickles RJ, Baric RS, Garcia JV. SARS-CoV-2 infection is effectively treated and prevented by EIDD-2801. Nature. 2021 Mar;591(7850):451-457. doi: 10.1038/s41586-021-03312-w. PMID: 33561864. PMCID: PMC7979515.
  8. Tanno LK, Demoly P, Martin B, Berstein J, Morais-Almeida M, Levin M, Fiocchi A, Sanchez-Borges M, Caraballo LR, Wong G, Ortega-Martell JA, Rouadi P, Yanez A, Wang LL, Peden DB, Chikhadze M, Gonzalez-Diaz SN, Fontaine JF, Sublett J, Chang YS, Passalacqua G, Ansotegui I, Ebisawa M, Senna G, Caminati M. Allergy and coronavirus disease (COVID-19) international survey: Real-life data from the allergy community during the pandemic. World Allergy Organ J. 2021 Feb;14(2):100515. doi: 10.1016/j.waojou.2021.100515. PMID: 33552380; PMCID: PMC7847410.
  9. Lai SK, McSweeney MD, Pickles RJ. Learning from past failures: Challenges with monoclonal antibody therapies for COVID-19. J Control Release. 2021 Jan 10;329:87-95. doi: 10.1016/j.jconrel.2020.11.057. PMID: 33276017; PMCID: PMC7836766.
  10. Hou YJ, Chiba S, Halfmann P, Ehre C, Kuroda M, Dinnon KH 3rd, Leist SR, Schäfer A, Nakajima N, Takahashi K, Lee RE, Mascenik TM, Graham R, Edwards CE, Tse LV, Okuda K, Markmann AJ, Bartelt L, de Silva A, Margolis DM, Boucher RC, Randell SH, Suzuki T, Gralinski LE, Kawaoka Y, Baric RS. SARS-CoV-2 D614G variant exhibits efficient replication ex vivo and transmission in vivo. Science. 2020 Dec 18;370(6523):1464-1468. doi: 10.1126/science.abe8499. PMID: 33184236. PMCID: PMC7775736.
  11. Sickbert-Bennett EE, Samet JM, Clapp PW, Chen H, Berntsen J, Zeman KL, Tong H, Weber DJ, Bennett WD. Filtration Efficiency of Hospital Face Mask Alternatives Available for Use During the COVID-19 Pandemic. JAMA Intern Med. 2020 Dec 1;180(12):1607-1612. doi: 10.1001/jamainternmed.2020.4221. PMID: 32780113; PMCID: PMC7420816.
  12. Leist SR, Dinnon KH 3rd, Schäfer A, Tse LV, Okuda K, Hou YJ, West A, Edwards CE, Sanders W, Fritch EJ, Gully KL, Scobey T, Brown AJ, Sheahan TP, Moorman NJ, Boucher RC, Gralinski LE, Montgomery SA, Baric RS. A Mouse-Adapted SARS-CoV-2 Induces Acute Lung Injury and Mortality in Standard Laboratory Mice. Cell. 2020 Nov 12;183(4):1070-1085.e12. doi: 10.1016/j.cell.2020.09.050. PMID: 33031744; PMCID: PMC7510428.
  13. Katsura H, Sontake V, Tata A, Kobayashi Y, Edwards CE, Heaton BE, Konkimalla A, Asakura T, Mikami Y, Fritch EJ, Lee PJ, Heaton NS, Boucher RC, Randell SH, Baric RS, Tata PR. Human Lung Stem Cell-Based Alveolospheres Provide Insights into SARS-CoV-2-Mediated Interferon Responses and Pneumocyte Dysfunction. Cell Stem Cell. 2020 Oct 21:S1934-5909(20)30499-9. doi: 10.1016/j.stem.2020.10.005. PMID: 33128895; PMCID: PMC7577733.
  14. Gentzsch M, Rossier BC. A Pathophysiological Model for COVID-19: Critical Importance of Transepithelial Sodium Transport upon Airway Infection. Function (Oxf). 2020 Oct 3;1(2):zqaa024. doi: 10.1093/function/zqaa024. PMID: 33201937; PMCID: PMC7662147.
  15. Hedrick TL, Murray BP, Hagan RS, Mock JR. COVID-19: Clean up on IL-6. Am J Respir Cell Mol Biol. 2020 Oct;63(4):541-543. doi: 10.1165/rcmb.2020-0277LE. PMID: 32750259; PMCID: PMC7528925.
  16. Barzin A, Schmitz JL, Rosin S, Sirpal R, Almond M, Robinette C, Wells S, Hudgens M, Olshan A, Deen S, Krejci P, Quackenbush E, Chronowski K, Cornaby C, Goins J, Butler L, Aucoin J, Boyer K, Faulk J, Alston-Johnson D, Page C, Zhou Y, Fiscus L, Damania B, Dittmer DP, Peden DB. SARS-CoV-2 Seroprevalence among a Southern U.S. Population Indicates Limited Asymptomatic Spread under Physical Distancing Measures. mBio. 2020 Sep 29;11(5):e02426-20. doi: 10.1128/mBio.02426-20. PMID: 32994333; PMCID: PMC7527736.
  17. Ehre C. SARS-CoV-2 Infection of Airway Cells. N Engl J Med. 2020 Sep 3;383(10):969. doi: 10.1056/NEJMicm2023328. PMID: 32877585; PMCID: PMC7484746.
  18. Cotter PA. My Experience with SARS-CoV-2, with a Focus on Testing. J Clin Microbiol. 2020 Jul 23;58(8):e01228-20. doi: 10.1128/JCM.01228-20. PMID: 32703893; PMCID: PMC7383536.
  19. Hou YJ, Okuda K, Edwards CE, Martinez DR, Asakura T, Dinnon KH 3rd, Kato T, Lee RE, Yount BL, Mascenik TM, Chen G, Olivier KN, Ghio A, Tse LV, Leist SR, Gralinski LE, Schäfer A, Dang H, Gilmore R, Nakano S, Sun L, Fulcher ML, Livraghi-Butrico A, Nicely NI, Cameron M, Cameron C, Kelvin DJ, de Silva A, Margolis DM, Markmann A, Bartelt L, Zumwalt R, Martinez FJ, Salvatore SP, Borczuk A, Tata PR, Sontake V, Kimple A, Jaspers I, O’Neal WK, Randell SH, Boucher RC, Baric RS. SARS-CoV-2 Reverse Genetics Reveals a Variable Infection Gradient in the Respiratory Tract. Cell. 2020 Jul 23;182(2):429-446.e14. doi: 10.1016/j.cell.2020.05.042. PMID: 32526206; PMCID: PMC7250779.
  20. Polidoro RB, Hagan RS, de Santis Santiago R, Schmidt NW. Overview: Systemic Inflammatory Response Derived From Lung Injury Caused by SARS-CoV-2 Infection Explains Severe Outcomes in COVID-19. Front Immunol. 2020 Jun 26;11:1626. doi: 10.3389/fimmu.2020.01626. PMID: 32714336; PMCID: PMC7344249.
  21. Morais-Almeida M, Aguiar R, Martin B, Ansotegui IJ, Ebisawa M, Arruda LK, Caminati M, Canonica GW, Carr T, Chupp G, Corren J, Dávila I, Park HS, Hanania NA, Rosenwasser L, Sánchez-Borges M, Virchow JC, Yáñez A, Bernstein JA, Caraballo L, Chang YS, Chikhladze M, Fiocchi A, González-Diaz SN, Tanno LK, Levin M, Ortega-Martell JA, Passalacqua G, Peden DB, Rouadi PW, Sublett JL, Wong GWK, Bleecker ER. COVID-19, asthma, and biological therapies: What we need to know. World Allergy Organ J. 2020 May 16;13(5):100126. doi: 10.1016/j.waojou.2020.100126. PMID: 32426090; PMCID: PMC7229954.

COVID-19-Related News Stories Featuring MLI Researchers