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UBE2R and S image

4 years ago

New pub in EMBO: Functional conservation and divergence of the helix-turn-helix motif of E2 ubiquitin-conjugating enzymes

Conserved helix-turn-helix motif contributes differentially to #polyubiquitination in various #cellcycle E2 enzymes - via distinct donor/acceptor #ubiquitin interactions. A collaborative effort led by Kaeli Welsh (UNC Pharmacology) who is the lead author amongst the colleagues, Nick Brown (Pharmacology) and Joe Harrison (a former postdoc in Kuhlman lab) and in BCBP (Josh Boyer, Brenda Temple, Derek Bolhuis, Qi Zhang) and other colleagues.

Klaus Hahn and Tim Elston rainbow cell image in Cell publication 2021

4 years ago

Powerful Technique Allows UNC Scientists to Study for First Time How Proteins Change Shape Inside Cells (Onur Dagliyan PhD, 2016 Alum)

This new method, created by the UNC School of Medicine labs of Klaus Hahn and Tim Elston, has the potential to super-charge the study of human proteins as they interact and change their conformations in fundamentally important ways in human health and disease. This research was a collaboration with many UNC departments and The Howard Hughes Medical Institute and was published in Cell!