DPLM Faculty Profiles — Dr. Xiao

Hong Xiao

Hong Xiao, MD

Associate Professor

Office: 919-966-2421

E-mail: hongx@med.unc.edu

Research Interests

My research interests are around immune-mediated glomerular diseases and vasculitis. My current studies focus on defining the immunopathological mechanisms involved in autoimmune glomerulonephritis and vasculitis with particular emphasis on understanding the role of anti-neutrophil cytoplasmic autoantibodies (MPO-ANCA and Pr3-ANCA) in the pathogenesis of glomerular/vascular injury. In the past years, I generated a MPO-ANCA disease mouse model that facilitated the studies of the mechanisms of the ANCA disease. By using this mouse model, I have studied the role of inflammatory cells, cytokines and complements in the pathogenesis of ANCA disease. Recently I have been working on developing a Pr3-ANCA mouse disease model as well. My goal aims to find out potential targets for therapeutic intervention of ANCA glomerulonephritis and vasculitis.

Selected Publications

Huugen D, van Esch A, Xiao H, Peutz-kootstra CJ, Buuman WA, Tervaert JW, Jennette JC, Herringa P.Inhibition of complement factor C5 protects against anti-myeloperoxidase antibody-mediated glomerulonephritis in mice. Kidney Int. 2007 Apr; 71(7):646-54.

Xiao H, Schreiber A, Heeringa P, Falk RJ, Jennette JC: Alternative Complement Pathway in the Pathogenesis of Disease Mediated by Anti-Neutrophil Cytoplasmic Autoantibodies. Am J Pathol January 2007, Vol. 170 (1): 52-64.

Schreiber A, Xiao H, Falk RJ, Jennette JC. Bone Marrow-Derived Cells Are Sufficient and Necessary Targets to Mediate Glomerulonephritis and Vasculitis Induced by Anti-Myeloperoxidase Antibodies. J Am Soc Nephrol 2006 Dec; 17 (12): 3355-64.

Jennette JC, Xiao H, Falk RJ. Pathogenesis of vascular inflammation by anti-neutrophil cytoplasmic antibodies. J Am Soc Nephrol 2006 May, 17(5):1235-42.

Xiao H, Heeringa P, Liu Z, Huugen D, Hu P, Falk RJ, Jennette JC: A major role for neutrophils in anti-myeloperoxidase antibody induced necrotizing and crescentic glomerulonephritis. Am J Pathol 167:39-45, 2005.

Huugen D, Xiao H, Jennette JC, Heeringa P: Aggravation of anti-myeloperoxidase antibody induced glomerulonephritis by bacterial lipopolysaccharide: role of tumor necrosis factor a. Am J Pathol 167:47-58, 2005.

Xiao H, Heringa Peter, Hu P, Liu Z, Zhao M, Aratani Y, Maeda NN, Falk RJ, Jennette JC. Antineutrophil Cytoplasmic Autoantibodies Specific for Myeloperoxidase Cause Glomerulonephritis and Vesculitis in Mice. J Clin Invest 2002; 110:955-963.

Preston GA, Yang JJ, Xiao H, Falk RJ. Understanding the pathogenesis of ANCA: where are we today? Cleve Clin J Med 2002; 69 Suppl 2:SII51-4.