Hong Xiao, MD
My research interests are around immune-mediated glomerular diseases and vasculitis. My current studies focus on defining the immunopathological mechanisms involved in autoimmune glomerulonephritis and vasculitis with particular emphasis on understanding the role of anti-neutrophil cytoplasmic autoantibodies (MPO-ANCA and Pr3-ANCA) in the pathogenesis of glomerular/vascular injury. In the past years, I generated a MPO-ANCA disease mouse model that facilitated the studies of the mechanisms of the ANCA disease. By using this mouse model, I have studied the role of inflammatory cells, cytokines and complements in the pathogenesis of ANCA disease. Recently I have been working on developing a Pr3-ANCA mouse disease model as well. My goal aims to find out potential targets for therapeutic intervention of ANCA glomerulonephritis and vasculitis.
Huugen D, van Esch A, Xiao H, Peutz-kootstra CJ, Buuman WA, Tervaert JW, Jennette JC, Herringa P.Inhibition of complement factor C5 protects against anti-myeloperoxidase antibody-mediated glomerulonephritis in mice. Kidney Int. 2007 Apr; 71(7):646-54.
Xiao H, Schreiber A, Heeringa P, Falk RJ, Jennette JC: Alternative Complement Pathway in the Pathogenesis of Disease Mediated by Anti-Neutrophil Cytoplasmic Autoantibodies. Am J Pathol January 2007, Vol. 170 (1): 52-64.
Schreiber A, Xiao H, Falk RJ, Jennette JC. Bone Marrow-Derived Cells Are Sufficient and Necessary Targets to Mediate Glomerulonephritis and Vasculitis Induced by Anti-Myeloperoxidase Antibodies. J Am Soc Nephrol 2006 Dec; 17 (12): 3355-64.
Jennette JC, Xiao H, Falk RJ. Pathogenesis of vascular inflammation by anti-neutrophil cytoplasmic antibodies. J Am Soc Nephrol 2006 May, 17(5):1235-42.
Xiao H, Heeringa P, Liu Z, Huugen D, Hu P, Falk RJ, Jennette JC: A major role for neutrophils in anti-myeloperoxidase antibody induced necrotizing and crescentic glomerulonephritis. Am J Pathol 167:39-45, 2005.
Huugen D, Xiao H, Jennette JC, Heeringa P: Aggravation of anti-myeloperoxidase antibody induced glomerulonephritis by bacterial lipopolysaccharide: role of tumor necrosis factor a. Am J Pathol 167:47-58, 2005.
Xiao H, Heringa Peter, Hu P, Liu Z, Zhao M, Aratani Y, Maeda NN, Falk RJ, Jennette JC. Antineutrophil Cytoplasmic Autoantibodies Specific for Myeloperoxidase Cause Glomerulonephritis and Vesculitis in Mice. J Clin Invest 2002; 110:955-963.
Preston GA, Yang JJ, Xiao H, Falk RJ. Understanding the pathogenesis of ANCA: where are we today? Cleve Clin J Med 2002; 69 Suppl 2:SII51-4.