DPLM Faculty Profiles — Dr. Thorne

Leigh Thorne

Leigh B. Thorne, MD

Professor

Office: 919-966-8003

Email: lthorne@unch.unc.edu

Research Interests

Molecular pathology, muscle pathology, autopsy pathology, and tissue banking.

Selected Publications

Bookhout C, Moylan V, Thorne LB. Two fatal herpesvirus cases: Treatable but easily missed diagnoses. IDCases. 2016 Sep 23;6:65-67. eCollection 2016. PMID: 27747159.

Allott EH, Cohen SM, Geradts J, Sun X, Khoury T, Bshara W, Zirpoli GR, Miller CR, Hwang H, Thorne LB, O'Connor S, Tse CK, Bell MB, Hu Z, Li Y, Kirk EL, Bethea TN, Perou CM, Palmer JR, Ambrosone CB, Olshan AF, Troester MA. Performance of Three-Biomarker Immunohistochemistry for Intrinsic Breast Cancer Subtyping in the AMBER Consortium. Cancer Epidemiol Biomarkers Prev. 2016 Mar;25(3):470-8. doi: 10.1158/1055-9965.EPI-15-0874. Epub 2015 Dec 28. PMID: 26711328.

Zhao N, Wilkerson MD, Shah U, Yin X, Wang A, Hayward MC, Roberts P, Lee CB, Parsons AM, Thorne LB, Haithcock BE, Grilley-Olson JE, Stinchcombe TE, Funkhouser WK, Wong KK, Sharpless NE, Hayes DN. Alterations of LKB1 and KRAS and risk of brain metastasis: comprehensive characterization by mutation analysis, copy number, and gene expression in non-small-cell lung carcinoma. Lung Cancer. 2014 Nov;86(2):255-61. doi: 10.1016/j.lungcan.2014.08.013. Epub 2014 Aug 30. PMID: 25224251.

Ryan JL, Shen YJ, Morgan DR, Thorne LB, Kenney SC, Dominguez RL, Gulley ML. Epstein-Barr virus infection is common in inflamed gastrointestinal mucosa. Dig Dis Sci. 2012 Jul;57(7):1887-98. doi: 10.1007/s10620-012-2116-5. Epub 2012 Mar 13. PMID: 22410851.

Sigel CS, Harper TC, Thorne LB. Postpartum sudden death from pulmonary hypertension in the setting of portal hypertension. Obstetrics and Gynecology. 2007 Aug;110(2):501-3.

Thorne LB, Civalier C, Booker JFan H,Gulley ML. Analytic Validation of a Quantitative Real-Time PCR Assay to Measure CMV Viral Load in Whole Blood. Diagn Mol Pathol. 2007 Jun;16(2):73-80.

Scanga L, Chaing S, Powell C, Aylsworth AS, Harrell LJ, Henshaw NG, Civalier CJ, Thorne LB, Weck K, Booker J, Gulley ML. Diagnosis of human congenital cytomegalovirus infection by amplification of viral DNA from dried blood spots on perinatal cards. J Mol Diagn. 2006 May; 8(2):240-5.

Thorne LB, Ryan JL, Elmore SH, Glaser SL, Gulley ML.Real-time PCR measures Epstein-Barr Virus DNA in archival breast adenocarcinomas.Diagn Mol Pathol. 2005 Mar;14(1):29-33.

View list of publications from PubMed