DPLM Faculty Profiles — Dr. Miller

Melissa Miller

Melissa B. Miller, PhD

Associate Professor

Director, Clinical Molecular Microbiology Laboratory

Associate Director, Clinical Microbiology Laboratory

Office: 919-966-3723

E-mail: mbmiller@unch.unc.edu

Research Interests

My research interests include the use of molecular methodologies to understand the basis of clinical treatment failures and inaccurate laboratory diagnoses with regard to infectious diseases. As the Director of the Molecular Microbiology Laboratory for UNC Hospitals, I am interested in the use of real-time PCR to develop more accurate, cost-effective and timely laboratory tests. Many of these clinical assays are used as research tools to address specific infectious disease questions, such as the prevalence and epidemiology of antimicrobial resistance. In addition, I am interested in the application of molecular techniques in the diagnosis of tuberculosis and respiratory viral diseases and outcome studies aimed at measuring the clinical and financial impact of new diagnostic tests and algorithms.

Selected Publications

Alby K, Daniels LM, Weber DJ, Miller MB. Development of a treatment algorithm for streptococci/enterococci from positive blood cultures identified with the Verigene BC-GP assay. J Clin Microbiol, 2013 Aug 28. [Epub ahead of print]

Alby K, Gilligan PH, Miller MB. Comparison of MALDI-TOF mass spectrometry platforms for the identification of gram negative rods from Cystic Fibrosis patients. J Clin Microbiol, 2013 Aug 21. [Epub ahead of print]

Champion EA, Miller MB, Popowitch EB, Hobbs MM, Saiman L, Muhlebach MS; for the STAR-CF Study Team. Antimicrobial susceptibility and molecular typing of MRSA in cystic fibrosis. Ped Pulmonol, 2013 Jun 14. doi: 10.1002/ppul.22815. [Epub ahead of print]

Popowitch EB, O'Neill SS, Miller MB. Comparison of the BioFire FilmArray RP, Genmark eSensor RVP, Luminex xTAG RVPv1 and Luminex xTAG RVP FAST multiplex assays for the detection of respiratory viruses. J Clin Microbiol, 2013, 51:1528-1533.

Culton DA, Lachiewicz AM, Miller BA, Miller MB, MacKuen C, Groben P, White B, Cox GM, Stout JE. Nontuberculous mycobacterial infection after fractionated carbon dioxide laser resurfacing. Emerg Infect Dis, 2013, 19:365-370.

Alby K, Popowitch EB, Miller MB. Comparative evaluation of the Nanosphere Verigene RV+ assay with the Simplexa Flu A/B & RSV Kit for the detection of influenza and respiratory syncytial viruses. J Clin Microbiol, 2013; 51:352-353.

Balakrishnan N, Jawanda JS, Miller MB, Breitschwerdt EB. Bartonella henselae infection in a man with hypergammaglobulinemia, splenomegaly and polyclonal plasmacytosis. J Med Microbiol, 2013, 62:338-341.

Heil EL, Daniels LM, Long DM, Rodino KG, Weber DJ, Miller MB. Impact of a rapid peptide nucleic acid fluorescence in situ hybridization assay on treatment of Candida infections. Am J Health Syst Pharm, 2012, 60:1910-1914.

Moss HB, Chavala S, Say E, Miller MB. Ganciclovir-resistant CMV retinitis in a patient with wild-type CMV in her plasma. J Clin Microbiol, 2012; 50:1796-1799.

Miller MB, Popowitch EB, Backlund MG, Ager EP. Performance of Xpert MTB/RIF RUO assay and IS6110 real-time PCR for Mycobacterium tuberculosis detection in clinical samples. J Clin Microbiol, 2011, 49:3458-3462.

Stout JE, Gadkowski LB, Rath S, Alspaugh JA, Miller MB, Cox GM. Pedicure-associated rapidly growing mycobacterial infection: an endemic disease. Clin Infect Dis, 2011; 53:787-792.

Popowitch EB, Rogers E, Miller MB. Retrospective and prospective verification of the Cepheid Xpert Flu assay. J Clin Microbiol, 2011, 49:3368-3369.

Alexander TS and Miller MB. Point-Counterpoint: Should interferon game release assays become the standard method for screening patients for Mycobacterium tuberculosis infections in the United States? J Clin Microbiol, 2011; 49:2086-2092.

Muhlebach MS, Miller M, LaVange L, Goodrich JS, Miller MB. Treatment intensity and characteristics of MRSA infection in CF. J Cyst Fibros, 2011; 10:201-206.

Wertman R, Miller MB, Groben P, Morrell DS, Culton DA. Mycobacterium bolletii/massiliense furunculosis associated with pedicure footbaths: a report of three cases. Arch Dermatol, 2011; 147(4):454-8.

Miller MB, Weber DJ, Goodrich JS, Popowitch EB, Poe MD, Nyugen V, Shope TR, Foster DT, Miller JR, Kotch J. Prevalence and risk factors for MRSA colonization in children attending child care centers. J Clin Microbiol, 2011; 49:1041-1047.