Xue Bai, PhD

Xue Bai, PhD

Assistant Professor

Office: 919-843-5512
E-mail: Xue_Bai@med.unc.edu

Research Interests

Molecular and functional roles of RhoGaps in hypertension and metabolism regulation

Selected Publications

Bai X, Mangum K, Kakoki M, Smithies O, Mack CP, Taylor JM. GRAF3 serves as a blood volume-sensitive rheostat to control smooth muscle contractility and blood pressure. Small GTPases. 2017 Nov 3:1-10. doi: 10.1080/21541248.2017.1375602. [Epub ahead of print] PubMed PMID: 29099324.

Bai X, Mangum KD, Dee RA, Stouffer GA, Lee CR, Oni-Orisan A, Patterson C, Schisler JC, Viera AJ, Taylor JM, Mack CP. Blood pressure-associated polymorphism controls ARHGAP42 expression via serum response factor DNA binding. J Clin Invest. 2017 Feb 1;127(2):670-680. doi: 10.1172/JCI88899. Epub 2017 Jan 23. PubMed PMID: 28112683; PubMed Central PMCID: PMC5272192.

Bai X, Lenhart KC, Bird KE, Suen AA, Rojas M, Kakoki M, Li F, Smithies O, Mack CP, Taylor JM. The smooth muscle-selective RhoGAP GRAF3 is a critical regulator of vascular tone and hypertension. Nat Commun. 2013;4:2910. doi: 10.1038/ncomms3910. PubMed PMID: 24335996; PubMed Central PMCID: PMC4237314.

Bai X, Margariti A, Hu Y, Sato Y, Zeng L, Ivetic A, Habi O, Mason JC, Wang X, Xu Q. Protein kinase C{delta} deficiency accelerates neointimal lesions of mouse injured artery involving delayed reendothelialization and vasohibin-1 accumulation. Arterioscler Thromb Vasc Biol. 2010 Dec;30(12):2467-74. doi: 10.1161/ATVBAHA.110.215723. Epub 2010 Sep 30. PubMed PMID: 20884873.

Zheng S, Li W, Xu M, Bai X, Zhou Z, Han J, Shyy JY, Wang X. Calcitonin gene-related peptide promotes angiogenesis via AMP-activated protein kinase. Am J Physiol Cell Physiol. 2010 Dec;299(6):C1485-92. doi: 10.1152/ajpcell.00173.2010. Epub 2010 Sep 29. PubMed PMID: 20881236.

Bai X, Wang X, Xu Q. Endothelial damage and stem cell repair in atherosclerosis. Vascul Pharmacol. 2010 May-Jun;52(5-6):224-9. doi: 10.1016/j.vph.2010.02.001. Epub 2010 Feb 13. Review. PubMed PMID: 20156585.

Wang L, Zheng J, Bai X, Liu B, Liu CJ, Xu Q, Zhu Y, Wang N, Kong W, Wang X. ADAMTS-7 mediates vascular smooth muscle cell migration and neointima formation in balloon-injured rat arteries. Circ Res. 2009 Mar 13;104(5):688-98. doi: 10.1161/CIRCRESAHA.108.188425. Epub 2009 Jan 22. PubMed PMID: 19168437.